{"id":362,"date":"2020-09-14T12:35:49","date_gmt":"2020-09-14T10:35:49","guid":{"rendered":"https:\/\/lpinstitute.dev.onpressidium.com\/news\/5f5f88e5b677db38abb1ed56\/"},"modified":"2025-11-06T22:44:30","modified_gmt":"2025-11-06T21:44:30","slug":"les-schtroumpfs-se-font-anred","status":"publish","type":"post","link":"https:\/\/www.learningplanetinstitute.org\/fr\/news\/les-schtroumpfs-se-font-anred\/","title":{"rendered":"Les Schtroumpfs se font ANRed"},"content":{"rendered":"<p>Le vieillissement est consid\u00e9r\u00e9, chez les humains et les organismes utilis\u00e9s pour mod\u00e9liser leur vieillissement, comme <a href=\"https:\/\/science.sciencemag.org\/content\/139\/3553\/400.1\/tab-pdf\" rel=\"noopener nofollow\">un processus continu<\/a> qui s&#8217;accompagne d&#8217;un risque de mortalit\u00e9 croissant en fonction du temps et de ce que l&#8217;on appelle les <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3836174\/\" rel=\"noopener nofollow\">caract\u00e9ristiques du vieillissement<\/a>. Gr\u00e2ce \u00e0 un outil<a href=\"https:\/\/www.researchgate.net\/publication\/51772019_Modulation_of_Longevity_and_Tissue_Homeostasis_by_the_Drosophila_PGC-1_Homolog\" rel=\"noopener nofollow\">(l&#8217;essai Schtroumpf<\/a>) et \u00e0 un cadre th\u00e9orique (Two phases of ageing &#8211; 2PAC) d\u00e9velopp\u00e9s par <a href=\"https:\/\/research.cri-paris.org\/profile?id=7ea72ecd-84f5-4318-8666-ffbc993a92ea\" rel=\"noopener nofollow\">Michael Rera<\/a> au cours des derni\u00e8res ann\u00e9es, initialement en utilisant l&#8217;organisme mod\u00e8le <em>D. melanogaster, <\/em>cette vision du vieillissement peut maintenant \u00eatre remise en question et ouvre de nouvelles questions concernant ce processus.<\/p>\n<p>Nous pouvons maintenant \u00e9tudier le <a href=\"https:\/\/www.researchgate.net\/publication\/233909455_Intestinal_barrier_dysfunction_links_metabolic_and_inflammatory_markers_of_aging_to_death_in_Drosophila\" rel=\"noopener nofollow\">vieillissement comme un processus discontinu<\/a> compos\u00e9 de deux phases successives s\u00e9par\u00e9es par une transition brutale, <a href=\"https:\/\/www.researchgate.net\/publication\/282503841_Two_phases_of_aging_separated_by_the_Smurf_transition_as_a_public_path_to_death\" rel=\"noopener nofollow\">\u00e9volutivement conserv\u00e9e<\/a> chez d&#8217;autres esp\u00e8ces de drosophiles, les n\u00e9matodes et le poisson-z\u00e8bre. Gr\u00e2ce \u00e0 la bourse ATIP-Avenir qu&#8217;il a obtenue en 2018, avec son \u00e9quipe ils ont commenc\u00e9 \u00e0 caract\u00e9riser la signature transcriptionnelle de chacune de ces deux phases en fonction de l&#8217;\u00e2ge chronologique ainsi que sa conservation chez les mammif\u00e8res, et \u00e0 esquisser les <a href=\"https:\/\/www.researchgate.net\/publication\/341932090_Ethical_and_social_implications_of_approaching_death_prediction_in_humans_-_when_the_biology_of_ageing_meets_existential_issues\" rel=\"noopener nofollow\">questions \u00e9thiques<\/a> que soul\u00e8vent nos travaux de recherche&#8230;.<\/p>\n<p>Le projet ADAGIO financ\u00e9 par l&#8217;ANR a pour objectif 1) d&#8217;\u00e9tendre ces outils aux mammif\u00e8res dont l&#8217;homme et 2) de caract\u00e9riser les changements m\u00e9taboliques accompagnant la phase tardive de la vie afin de 3) d\u00e9velopper des marqueurs encore plus pr\u00e9coces de la mort naturelle.<\/p>\n<p>Nous consid\u00e9rons qu&#8217;il s&#8217;agit l\u00e0 des premi\u00e8res \u00e9tapes essentielles pour cr\u00e9er de nouvelles interventions pharmacologiques et g\u00e9n\u00e9tiques anti-\u00e2ge plus efficaces.<\/p>\n<p><u>addendum<\/u>: deux descriptions de poste seront bient\u00f4t publi\u00e9es pour un poste de postdoc de 24 mois ainsi que pour un poste d&#8217;ing\u00e9nieur de 18 mois avec une forte expertise sur les souris et un contrat de doctorant<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project led by Michael Rera, who joined the CRI as a core fellows in june 2020,  has been awarded  a grant from Agence Nationale de la recherche for the project ADAGIO that will investigate the driving mechanisms of ageing<\/p>\n","protected":false},"author":5,"featured_media":363,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[20],"tags":[],"class_list":["post-362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rd"],"acf":[],"meta_box":[],"_links":{"self":[{"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/posts\/362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/comments?post=362"}],"version-history":[{"count":0,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/posts\/362\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/media\/363"}],"wp:attachment":[{"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/media?parent=362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/categories?post=362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.learningplanetinstitute.org\/fr\/wp-json\/wp\/v2\/tags?post=362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}